S-nitrosoglutathionreduktasa: klíčový enzym regulace S-nitrosylace

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S-nitrosylation has recently emerged as an ubiquitous posttranslational protein modification. S-nitrosothiols, which can serve as stable and mobile reservoirs of nitric oxide, show convergence of signalling pathways of reactive nitrogen and oxygen species. This review summarizes the current knowledge of S-nitrosoglutathione reductase (GSNOR), a key enzyme involved in the regulation of intracellular levels of S-nitrosoglutathione and protein S-nitrosothiols. The biological functions of GSNOR are based on its ability to decompose GSNO with concomitant production of oxidized glutathione. Altered expression and levels of GSNOR have been found associated with important pathological processes. Similarly, GSNOR is involved in signalling mechanisms and defence responses of plants to various abiotic and biotic stress stimuli. Despite recent considerable advances in S-nitrosothiol research, our understanding of signalling pathways and GSNORmediated catabolism of GSNO in vivo are still limited. Current research involves studies of the role of GSNOR in human pathophysiological processes and in plant response to stress conditions. … full description

Bibliographic Details

Other Authors

Lucie Kubienová, Tereza Tichá, Jana Jahnová, Lenka Luhová, 1961- , Marek Petřivalský, 1969-

Document Type

Articles

Physical Description

3 il.

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 107, č. 3 (2013), s. 202-208

Subjects

GLUTATHIONE REDUCTASE

ENZYMES

PROTEINS

ENZYME ACTIVITY

GLUTATHIONE

biotic stress

abiotic stress

PLANTS

Abiotic injuries

NITRIC OXIDE

glutathionreduktáza

enzymy

bílkoviny

enzymatická aktivita

glutathion

biotický stres

abiotické faktory

rostliny

abiotické poškození

oxid dusnatý

metabolické dráhy > nitrosylace

Item Description

Schemata

Bibliography

Literatura na s. 207-208 (51 zázn.)