Výsledky vyhledávání - "Erb"

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    “…The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to play key roles in the regulation of numerous physiological functions, such as metabolism and the circadian rhythm…”
    Journal Article
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    “…The nuclear receptors REV-ERBα (encoded by NR1D1 ) and REV-ERBβ ( NR1D2 ) have remained orphans owing to the lack of identified physiological ligands…”
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    “… The nuclear receptors REV-ERBα and REV-ERBβ are involved in the cell-autonomous circadian transcriptional/translational feedback loops as transcriptional repressors…”
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    “… We investigated the potential role of the circadian clock components Rev‐erb‐α/β in regulation of ferroptosis and AKI…”
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    Hlavní autor Wang, Shuai, Lin, Yanke, Yuan, Xue, Li, Feng, Guo, Lianxia, Wu, Baojian
    Publikováno v Nature communications (12. 10. 2018)
    “…The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified…”
    Journal Article
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    “…The nuclear receptor Rev-erbα, a powerful repressor of transcription, is shown to link circadian and thermogenic networks by regulating the function of brown adipose tissue…”
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    “… The nuclear receptors REV-ERB-α and REV-ERB-β have an integral role in regulating the expression of core clock proteins driving rhythms in activity and metabolism…”
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    “… We found that in mice, circadian gene expression in the liver is controlled by rhythmic chromatin interactions between enhancers and promoters. Rev-erbα…”
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    “… Here, we show that REV-ERBα, a core inhibitory component of clock transcription, is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7…”
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    “…The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members of the circadian clock and participate in the regulation of a diverse set of metabolic functions…”
    Journal Article
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