Single centre clinical experience with fidaxomicin in the treatment of Clostridium difficile infection in Slovakia

To chci

OBJECTIVE: Clostridium difficile infection (CDI) has become one of the most common causes of hospital-acquired infections. Fidaxomicin is one of the latest antibiotics used in the treatment of CDI, however, treatment cost affects recommendations for its use in several countries. We have analysed the treatment of our patients with CDI, treated by fidaxomicin since it was introduced to the market in 2018 and became available in the second biggest Slovak hospital, University Hospital of L. Pasteur. Our aim was to determine efficacy and safety of fidaxomicin in the treatment of CDI in Slovak patients. METHODS: We reviewed all courses of fidaxomicin use in our hospital (n = 60). Fidaxomicin was used for first recurrence (12 times), second recurrence (4 times), third recurrence (2 times), and fifth recurrence (1 patient). 41 patients received fidaxomicin first-line. RESULTS: Success of fidaxomicin treatment was recorded at 86.7% within the whole cohort. In the recurrent Clostridium difficile infection (rCDI) subgroup, fidaxomicin was 63% effective with three patients dying (15.7%) and two patients developing subsequent rCDI. During the duration of the study, 6 patients in total died. Only one of three patients, with three or more recurrences of CDI, had no further presentations after eight weeks of completion of treatment. CONCLUSIONS: The biggest benefit from fidaxomicin treatment was shown in a cohort of patients with primary CDI infection demonstrating a low recurrence rate and significant reduction of fidaxomicin effectiveness in preventing a recurrence when treating patients with multiple rCDI. … celý popis

Podrobná bibliografie

Hlavní autor

Martin Novotný

Další autoři

Pavol Jarčuška , Laura Gombošová, 1967- , Ján Hockicko , Ivana Hockicková , Alena Rovňáková , Ondrej Zahornacký , Ivan Schréter , Erik Dorko , Kvetoslava Rimárová, 1958-

Typ dokumentu

Články

Publikováno v

Central European journal of public health. Trends in Communicable and Non-communicable Diseases in Eastern Slovakia. -- ISSN 1210-7778. -- Roč. 26, Suppl. (2018), s. S76-S80
Trends in communicable and non-communicable diseases in Eastern Slovakia. -- (2018), s. S76-S80

Témata

mladiství

dospělí

senioři

antibakteriální látky > terapeutické užití

dítě

klostridiové infekce > diagnóza > farmakoterapie

Clostridioides difficile > účinky léků > izolace a purifikace

fidaxomicin > terapeutické užití

lidé

lidé středního věku

výsledek terapie

mladý dospělý

Slovenská republika > epidemiologie

časopisecké články