DNA analysis of microdeletions in azf regions (Yq) in man with reproductive failure - our results

To chci

Male factor of infertility is the cause of reproductive failure in approximately 50% pairs and in about 50% cases is the cause of male infertility unknown. Microdeletions of the regions AZF (Yp) occur in about 4-5% men with oligospermia and in about 15–18% men with azoospermia. Material and methods: In pairs with reproductive failure we recommend genetic conselling and chromosomal analysis in both partners. Examination of microdeletions of AZF regions we performed in men with severe oligo- or azoospermia. Results: In 2000–2005 we performed this analysis in 549 men with patological count of sperms and we foud the microdeletions in 19 men (3.46%), between 1.89 and 5.43 %. In all 16 positive patients with microdeletion of AZF regions was azoopsermia, in three oligospermia (max. 1.2 mil/ml). Conclusions: According to our experience and literaty data we clarify indications criteria to analysis of microdeletions of AZF regions in men. We recommend this analysis in men with the count of sperms less then 2 millions in ml. Genetic counselling and genetic analysis is a very important part of assisted reproduction. The information about possibility of transmition some genetic failure on the child should be given before using the methods of asisted reproduction. … celý popis

Podrobná bibliografie

Hlavní autor

Renata Gaillyová, 1957-

Další autoři

Iveta Valášková , Igor Crha, 1955- , Pavel Ventruba, 1954- , Rastislav Beharka , Dalibor Pacík, 1955-

Typ dokumentu

Články

Publikováno v

Abstracts of the 2nd Czech and International Congress of Andrology. -- ISSN 1802-4793. -- Roč. 1, Suppl.1 (2007), s. 25

Témata

abstrakty

Popis jednotky

2. český a mezinárodní andrologický kongres, Štiřín, 3.-5.5.2007

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