Separace enantiomerů kathinonů kapilární elektroforézou s využitím cyklodextrinů jako chirálních selektorů = Separation of Enantiomers of Cathinones by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

To chci

This paper deals with a chiral separation of six cathinones using three commercially available cyclodextrins as additives to the background electrolyte consisting of a phosphate buffer at pH 2.5. The best resolution values were obtained by the addition of sulfated beta-cyclodextrin at 5 mmol L-1 concentration in the background electrolyte. Four complete chiral separations of racemic cathinones were achieved. Other two racemic cathinones were successfully enantioseparated by addition of carboxymethylated beta-cyclodextrin at 15 mmol L-1 concentration in the background electrolyte. For one of the cathinones analyzed, the apparent stability constants of beta-cyclodextrin and the average apparent stability constants of carboxy-methylated beta-cyclodextrin were calculated and it was found that a more stable complex is formed for carboxy-methylated beta-cyclodextrin. … celý popis

Podrobná bibliografie

Hlavní autor

Martina Hegrová

Další autoři

Klára Navrátilová
Martin Kuchař, 1980-
Pavel Řezanka, 1981-

Typ dokumentu

Články

Fyzický popis

3 ilustrace

Publikováno v

Chemické listy. -- ISSN 0009-2770. -- Roč. 110, č. 3 (2016), s. 200-203

Témata

CATHA EDULIS

ALKALOIDS

STIMULANTS

Analytical chemistry

ANALYTICAL METHODS

Cyclodextrins

SEPARATING

EFFICIENCY

calculation

ELECTROPHORESIS

ELECTROLYTES

VISCOSITY

buffers

PH

chirální selektory

kathinony

enantiomery

elektromigrační metody

konstanty stability

komplex PVP-CD

elektroforegramy

Catha edulis

alkaloidy

stimulanty

analytická chemie

analytické metody

cyklodextriny

separace

účinnost

výpočet

elektroforéza

elektrolyty

viskozita

pufry

pH

Popis jednotky

1 graf, 1 obrázek, 1 tabulka

Bibliografie

Literatura na s. 203 (18 zázn.)